Secondary hyperparathyroidism, anemia and treatment with 1.25(OH)2D3 in uremia.
نویسندگان
چکیده
منابع مشابه
How to evaluate hypercalcaemia in the patient with chronic renal failure.
In the normal human subject, the plasma concentration of ionized calcium is tightly regulated within an extremely narrow range [1]. The kidney plays an important role in normal calcium homeostasis. It regulates the excretion of calcium and phosphorus and is the site of production of 1,25(OH)2D3. Furthermore, it is one of the effector organs for calcium-regulating hormones, 1,25(OH)2D3 and PTH. ...
متن کاملMarked suppression of secondary hyperparathyroidism by intravenous administration of 1,25-dihydroxy-cholecalciferol in uremic patients.
Current evidence suggests that administration of 1,25(OH)2D3 to patients with chronic renal insufficiency results in suppression of secondary hyperparathyroidism only if hypercalcemia occurs. However, since the parathyroid glands possess specific receptors for 1,25(OH)2D3 and a calcium binding protein, there is considerable interest in a possible direct effect of 1,25(OH)2D3 on parathyroid horm...
متن کاملThe role of secondary hyperparathyroidism in anemia of end stage renal disease
Introduction: secondary hyperparathyroidism is listed among the possible reasons for intensifying the anemia and resistance to erythropoietin therapy in hemodialysis patients. Although its exact mechanism is not entirely clarified, but shift of bone marrow cells to adipocytes, bone marrow fibrosis and decreased calciteriol can be the causes. However, the role of secondary hyperparathyroidism in...
متن کاملDecreased 1,25-Dihydroxyvitamin D3 Receptor
The resistance of parathyroid cells to 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) in uremic hyperparathyroidism is thought to be caused, in part, by a 1,25(OH)2D3 receptor (VDR) deficiency in the parathyroids. However, results of biochemical studies addressing VDR numbers in the parathyroids are controversial. Several studies have found VDR content to be decreased in the parathyroids of uremic pati...
متن کاملCalreticulin inhibits vitamin D's action on the PTH gene in vitro and may prevent vitamin D's effect in vivo in hypocalcemic rats.
1,25-dihydroxyvitaminD3 [1,25-(OH)2D3] and PTH both act to increase serum calcium. In addition, 1,25-(OH)2D3 decreases PTH gene transcription, which is relevant both to the physiology of calcium homeostasis and to the management of the secondary hyperparathyroidism of patients with chronic renal failure. In chronic hypocalcemia there is secondary hyperparathyroidism with increased levels of PTH...
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ورودعنوان ژورنال:
- Nephron
دوره 45 3 شماره
صفحات -
تاریخ انتشار 1987